학술논문
Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin.
Document Type
Article
Source
Subject
*OBESITY
*GENETIC polymorphisms
*SEROTONIN transporters
*BODY composition
*HAPLOTYPES
DISEASES in adults
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Language
ISSN
1381-3455
Abstract
Objectives: To investigate the association of polymorphisms inSLC6A4andMAOAgenes with overweight (including obesity).Material and methods: Young adults (n = 535) of Portuguese origin were genotyped for theSLC6A4polymorphisms 5-HTTLPR and STin2 and aMAOAVNTR. BMI and body fat percentage were measured and a questionnaire was used to assess individual’s sport practicing habits.Results: In whole study sample, haplotype-based analysis revealed significant association with overweight/obesity for the individual 5-HTTLPR/Stin2 haplotype L10 (p = 0.04). In men, theMAOA3R genotype was nominally associated with body fat (p = 0.04). In inactive individuals, overweight/obesity was found significantly associated with 5-HTTLPR L-allele (p = 0.01) and nominally associated with STin2 10-allele (p = 0.03). A significant association was also found testing for all haplotype effects (χ2 = 8.7;p = 0.03).Conclusions: We found some evidences for the association ofSLC6A4andMAOAgenes with measures of obesity. Our results suggest physical inactivity accentuates the influence ofSLC6A4polymorphisms on obesity risk. [ABSTRACT FROM PUBLISHER]