학술논문
Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana
Document Type
Article
Author
Source
Subject
*LIGNANS
*X-ray crystallography
*ANTINEOPLASTIC agents
*BREAST cancer
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Language
ISSN
0968-0896
Abstract
Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8′R, and 7′R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines. [Copyright &y& Elsevier]