학술논문
The 5300-year-old Helicobacter pylori genome of the Iceman.
Document Type
Article
Author
Maixner, Frank, ; Krause-Kyora, Ben; Turaev, Dmitrij; Herbig, Alexander; Hoopmann, Michael R.; Hallows, Janice L.; Kusebauch, Ulrike; Egarter Vigl, Eduard; Malfertheiner, Peter; Megraud, Francis; O'Sullivan, Niall; Cipollini, Giovanna; Coia, Valentina; Samadelli, Marco; Engstrand, Lars; Linz, Bodo; Moritz, Robert L.; Grimm, Rudolf; Krause, Johannes; Nebel, Almut
Source
Subject
Language
ISSN
00368075
Abstract
The stomach bacterium Helicobacter pylori is one of the most prevalent human pathogens. It has dispersed globally with its human host, resulting in a distinct phylogeographic pattern that can be used to reconstruct both recent and ancient human migrations. The extant European population of H. pylori is known to be a hybrid between Asian and African bacteria, but there exist different hypotheses about when and where the hybridization took place, reflecting the complex demographic history of Europeans. Here, we present a 5300-year-old H. pylori genome from a European Copper Age glacier mummy. The "Iceman" H. pylori is a nearly pure representative of the bacterial population of Asian origin that existed in Europe before hybridization, suggesting that the African population arrived in Europe within the past few thousand years. [ABSTRACT FROM AUTHOR]