학술논문
Characteristics of B-Cell Lymphomas in HIV/HCV-Coinfected Patients During the Combined Antiretroviral Therapy Era.
Document Type
Article
Author
Terrier, Benjamin; Costagliola, Dominique; Prevot, Sophie; Chavez, Houria; Missy, Pascale; Rince, Patricia; Costello, Regis; Escaut, Lelia; Gabarre, Jean; Joly, Bertrand; Letranchant, Lorraine; Le Gouill, Steven; Morineau-Le Houssine, Pascale; Simon, Anne; Canioni, Danielle; Hermine, Olivier; Cacoub, Patrice; Taoufik, Yassine; Raphael, Martine; Besson, Caroline
Source
Subject
Language
ISSN
1525-4135
Abstract
Hepatitis C virus (HCV) infection is frequent among HIV-infected patients. We describe, the characteristics of 6 HIV/HCV-coinfected patients with B-cell non-Hodgkin lymphoma (NHL) included in a prospective cohort study of HIV-related lymphomas. Five of the 6 cases had features of marginal zone/lymphoplasmacytic NHL versus 1 of 33 HIV only-infected patients. Remarkably, anti-HCV treatment led to a hematological response in a patient with splenic marginal zone lymphoma. This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL. [ABSTRACT FROM AUTHOR]