학술논문
Chapter Five - Mathematical Inference on Helminth Egg Counts in Stool and Its Applications in Mass Drug Administration Programmes to Control Soil-Transmitted Helminthiasis in Public Health.
Document Type
Article
Author
Source
Subject
*TRANSMISSION of parasitic diseases
*HELMINTHIASIS
*DRUG administration
*PUBLIC health
*FECAL analysis
*DIAGNOSIS
*PREVENTION
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Language
ISSN
0065-308X
Abstract
In the present study, we present a hierarchical model based on faecal egg counts (FECs; expressed in eggs per 1 g of stool) in which we first describe the variation in FECs between individuals in a particular population, followed by describing the variance due to counting eggs under a microscope separately for each stool sample. From this general framework, we discuss how to calculate a sample size for assessing a population mean FEC and the impact of an intervention, measured as reduction in FECs, for any scenario of soil-transmitted helminth (STH) epidemiology (the intensity and aggregation of FECs within a population) and diagnostic strategy (amount of stool examined (~sensitivity of the diagnostic technique) and examination of individual/pooled stool samples) and on how to estimate prevalence of STH in the absence of a gold standard. To give these applications the most wide relevance as possible, we illustrate each of them with hypothetical examples. [ABSTRACT FROM AUTHOR]