학술논문
Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known M-Methyl-D-aspartate Receptor Allosteric Modulators.
Document Type
Article
Author
Source
Subject
*PHENANTHRENE synthesis
*METHYL aspartate receptors
*SUBSTITUENTS (Chemistry)
*ALLOSTERIC regulation
*CARBOXYLIC acids
*WITTIG reaction
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Language
ISSN
0039-7881
Abstract
9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N-methyl-D-aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter L-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain, and in neurodegenerative disorders such as Alzheimer's disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor. [ABSTRACT FROM AUTHOR]