학술논문
Association of FTO, KCNJ11, SLC30A8, and CDKN2B polymorphisms with type 2 diabetes mellitus.
Document Type
Article
Author
Source
Subject
*TYPE 2 diabetes
*GENETIC polymorphisms
*ZINC transporters
*GENE expression
*CYCLIN-dependent kinases
*HUMAN genes
*INSULIN
*RUSSIANS
*DISEASES
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Language
ISSN
0026-8933
Abstract
To test FTO, KCNJ11, SLC30A8, and CDKN2B for association with type 2 diabetes mellitus (DM), the allele and genotype frequency distributions were established for several polymorphisms of the genes. A comparison of allele and genotype frequencies between DM patients and healthy subjects implicated CKNJ11, SLC30A8, and CDKN2B, but not FTO, in the disease. The genes that affect insulin production and secretion in pancreatic β cells proved to play a main role in type 2 DM in the Russian population. [ABSTRACT FROM AUTHOR]