학술논문
Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium.
Document Type
Academic Journal
Author
Battler, Alexander; Scheinowitz, Mickey; Bor, Amir; Hasdai, David; Vered, Zvi; Di Segni, Elio; Varda-Bloom, Nira; Nass, Devorah; Engelberg, Santiago; Eldar, Michael; Belkin, Michael; Savion, Naphtali; Battler, A; Scheinowitz, M; Bor, A; Hasdai, D; Vered, Z; Di Segni, E; Varda-Bloom, N; Nass, D; et al
Source
Subject
Language
English
ISSN
0735-1097
Abstract
Objectives: This study was performed to examine the effect of intracoronary exogenous basic fibroblast growth factor (bFGF) on angiogenesis in infarcted myocardial regions.Background: Exogenous bFGF is a potent promoter of angiogenesis. Little information is available on its effect on myocardial angiogenesis.Methods: Myocardial infarction was induced in 10 pigs by intracoronary injection of microscopic beads. Four pigs served as a control group; in six pigs slow-release bFGF was delivered by the beads. Cardiac performance was evaluated by repeated echocardiographic measurement and angiogenesis was evaluated by immunohistochemical studies 14 days later.Results: As compared with control pigs, pigs treated with bFGF had higher microvessel counts (mean +/- SEM) in both viable tissue (141 +/- 27 per field vs. 39 +/- 4, p = 0.01) and nonviable tissue (329 +/- 26 per field vs. 95 +/- 7, p < 0.001) within the infarct area. No significant differences in total regional left ventricular wall motion were noted between the two groups throughout the 14-day study period.Conclusions: In the swine, direct intracoronary application of bFGF to infarcted myocardium enhances myocardial neovascularization within 2 weeks.