학술논문
Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia.
Document Type
Academic Journal
Author
Source
Subject
Language
English
ISSN
2152-2650
Abstract
Background: The prognosis of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) is very heterogeneous. Patients and Methods: We analyzed the prognostic value of several genes in a cohort of 85 MDS and AML patients. Results: Overexpression of glycogen synthase 1 and macrophage migration inhibitory factor genes had an adverse outcome in multivariate analysis (P = .003 and P < .001, respectively). Furthermore, the higher expression of myelocytomatosis oncogene was associated with a lower response to azacitidine (P = .03). Conclusion: In the current study we identified a specific gene expression profile as prognostic factors for response to azacitidine and survival in MDS and AML.