학술논문
Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: results from the Surgical Treatment for Ischemic Heart Failure trial.
Document Type
Academic Journal
Author
Mark DB; Knight JD; Velazquez EJ; Howlett JG; Spertus JA; Djokovic LT; Harding TM; Rankin GR; Drew LA; Szygula-Jurkiewicz B; Adlbrecht C; Anstrom KJ; Mark, Daniel B; Knight, J David; Velazquez, Eric J; Howlett, Jonathan G; Spertus, John A; Djokovic, Ljubomir T; Harding, Tina M; Rankin, Gena R; et al
Source
Subject
Language
English
ISSN
0002-8703
Abstract
Background: Surgical ventricular reconstruction (SVR) is used in conjunction with coronary artery bypass graft surgery (CABG) to improve left ventricular function and clinical outcomes in selected patients with ischemic heart failure. The impact of SVR on quality of life (QOL) and medical costs is unknown.Methods: We compared CABG plus SVR with CABG alone in 1,000 patients with ischemic heart failure, an anterior wall scar, and a left ventricular ejection fraction or=92% complete. Cost data were collected on 196 (98%) of 200 patients enrolled in the United States.Results: Heart-failure-related QOL outcomes did not differ between the 2 treatment strategies out to 3 years (median Kansas City Cardiomyopathy Questionnaire scores for CABG alone and CABG plus SVR, respectively: baseline 53 versus 54, P = .53; 3 years 85 versus 84, P = .89). There were no treatment-related differences in other QOL measures. In the US patients, total index hospitalization costs averaged over $14,500 higher for CABG plus SVR (P = .004) due primarily to 4.2 extra postoperative, high-intensity care days in the hospital.Conclusions: Addition of SVR to CABG in patients with ischemic heart failure did not improve QOL but significantly increased health care costs.