학술논문

Comparing suppository mold variability which can lead to dosage errors for suppositories prepared with the same or different molds.
Document Type
Periodical
Source
International Journal of Pharmaceutical Compounding (INT J PHARMACEUTICAL COMPOUND), 2013 Nov-Dec; 17(6): 512-514. (3p)
Subject
Language
English
ISSN
1092-4221
Abstract
Suppository molds must be properly calibrated to ensure accurate dosing. There are often slight differences between molds and even in the cavities within a mold. A method is presented for the calibration of standard aluminum 6-, 12-, 50-, or 100-well suppository molds. Ten different molds were tested using water for volume calibration, and cocoa butter for standardization involving establishing the density factor. This method is shown to be straightforward and appropriate for calibrating suppository molds.