부산대학교 도서관

Summary: ``Actin cytoskeletal protrusions in crawling cells, or lamellipodia,exhibitvarious morphological properties such as two characteristic peaks in thedistributionof filament orientation with respect to the leading edge. To understand theseproperties,using the dendritic nucleation model as a basis for cytoskeletal restructuring,akinetic-population model with orientational-dependent branching (birth) andcapping(death) is constructed and analyzed. Optimizing for growth yields a relationbetweenthe branch angle and filament orientation that explains the two characteristicpeaks.The model also exhibits a subdominant population that allows for more accuratemodelingof recent measurements of filamentous actin density along the leading edge oflamellipodia in keratocytes. Finally, we explore the relationship betweenorientationaland spatial organization of filamentous actin in lamellipodia and address recentobservationsof a prevalence of overlapping filaments to branched filaments---a finding thatis claimed to be in contradiction with the dendritic nucleation model.''