학술논문
Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort
Document Type
Journal Articles
Reports - Research
Reports - Research
Author
Palm, Camilla V. B.; Glintborg, Dorte (ORCID 0000-0002-8338-8025 ); Find, Laura G.; Larsen, Pia V.; Dalgaard, Cilia M.; Boye, Henriette; Jensen, Tina K.; Dreyer, Anja F.; Andersen, Marianne S.; Bilenberg, Niels
Source
Subject
Language
English
ISSN
0162-3257
1573-3432
1573-3432
Abstract
Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother-child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1 1/2-5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.