학술논문
A study of the association between one carbon metabolism and blood pressure in adults and transgenerationally between pregnant women and their children.
Document Type
Dissertation/Thesis
Author
Source
TDX (Tesis Doctorals en Xarxa)
Subject
Language
English
Abstract
El metabolisme monocarbonado y el polimorfismo MTHFR 677 C>T se ha asociado con la presión arterial y la hipertensión. Se cree que el mecanismo asociado es la programación fetal. Un estado adequado de nutrientes del metabolisme monocarbonado se ha asociado a efectos beneficiosos en la población adulta i en el embarazo, des de el desarrollo in utero hasta etapas posteriores de la vida incluyendo la infancia y la edad adulta. El objetivo de esta tesi es explorar las associaciones entre los nutrientes del metabolismo monocarbonado, incluyendo las vitaminas del grup B y la homocisteína así como el polimorfismo MTHFR 677C>T y la presión arterial i la hipertensión en dos poblaciones, una población adulta y un estudio madre-niño con un seguimiento durante el embarazo y al niño a los 7.5 años. 788 participantes seleccionados a partir del censo participaron en el estudio. Esta población no está expuesta a la fortificación de ácido fólico ni toman suplementos de vitaminas. Estar en el 3r tercil de tHcy aumenta el riesgo de hipertensión 1.8 veces [OR=1.8 (1.0, 3.3)] en la población total. Estratificando por edad sólo los >50 años encontraron una asociación con hipertensión [OR= 2.5 (1.2, 5.4)]. Ser TT aumenta el riesgo de hipertensión comparado con otros genotipos en todos los modelos de gente ≤ 50 años [OR= 8.2 (1.3, 53.9)]. En el Reus-Tarragona Birth Cohort 212 madre-niño díadas se siguieron durante el embarazo y los niños a los 7.5 años. La prevalencia de hipertensión en los niños era de 6.2%. El genotipo CT en el niño aumenta el riesgo de prehipertensión/hipertensión 6.5 veces [OR= 6.5 (1.0, 43.5)] ens los modelos de presión arterial en la consulta. El genotipo MTHFR 677 CT en las madres aumenta el riesgo de tener prehipertensión/ hipertensión 7.4 veces [OR= 7.4 (1.0, 55.0)] después de ajustar por factores clásicos de hipertensión.
One carbon metabolism nutrients and the MTHFR 677 C>T polymorphism have been found to be associated with blood pressure and hypertension. and the mechanism associated is thoughtIt is possible that the underlying mechanism may involve to be fetal programming.. An adequate status of 1C metabolism nutrients has been proven to be beneficial for some health outcomes in adults population and also in pregnancy, from in utero development until later in life including childhood and adulthood. The aim of this thesis is to explore the associations between 1C metabolism nutrients, including B-vitamins and tHcy, as well as the MTHFR 677C>T polymorphism, and blood pressure and hypertension in two different populations, an adult population and a mother-child study with follow-up during pregnancy and children at 7.5 years. Seven hundred and eighty eight participants randomly selected from the population town halls' registers participated in the population study. This population is unexposed to mandatory folic acid fortification and B vitamin supplement use. Being in the 3rd tertile of tHcy compared to the 1st increases the risk of having hypertension 1.8 times [OR=1.8 (1.0, 3.3)] in the total population. Stratifying for age, showed that the association in the >50 years group [OR= 2.5 (1.2, 5.4)] drives the overall result. only the people in the >50 years group showed an association with hypertension [OR= 2.5 (1.2, 5.4)]. Having the TT genotype increases the risk of having hypertension compared to the other genotypes in all models of people aged ≤ 50 years [OR= 8.2 (1.3, 53.9)]. In the Reus-Tarragona Birth Cohort two hundred and twelve mother-child dyads were followed up during pregnancy and children at 7.5 years. The prevalence of child hypertension was 6.2%. Child CT genotype increases the risk of having prehypertension/+hypertension 6.5 times [OR= 6.5 (1.0, 43.5)] in the office BP model. Maternal MTHFR 677 CT genotype increases the risk of having prehypertension/ hypertension and prehypertension 7.4 times [OR= 7.4 (1.0, 55.0)]. The association between the genotypes and prehypertension/ hypertension is maintained aftereven adjusting for classical other risk factors.
One carbon metabolism nutrients and the MTHFR 677 C>T polymorphism have been found to be associated with blood pressure and hypertension. and the mechanism associated is thoughtIt is possible that the underlying mechanism may involve to be fetal programming.. An adequate status of 1C metabolism nutrients has been proven to be beneficial for some health outcomes in adults population and also in pregnancy, from in utero development until later in life including childhood and adulthood. The aim of this thesis is to explore the associations between 1C metabolism nutrients, including B-vitamins and tHcy, as well as the MTHFR 677C>T polymorphism, and blood pressure and hypertension in two different populations, an adult population and a mother-child study with follow-up during pregnancy and children at 7.5 years. Seven hundred and eighty eight participants randomly selected from the population town halls' registers participated in the population study. This population is unexposed to mandatory folic acid fortification and B vitamin supplement use. Being in the 3rd tertile of tHcy compared to the 1st increases the risk of having hypertension 1.8 times [OR=1.8 (1.0, 3.3)] in the total population. Stratifying for age, showed that the association in the >50 years group [OR= 2.5 (1.2, 5.4)] drives the overall result. only the people in the >50 years group showed an association with hypertension [OR= 2.5 (1.2, 5.4)]. Having the TT genotype increases the risk of having hypertension compared to the other genotypes in all models of people aged ≤ 50 years [OR= 8.2 (1.3, 53.9)]. In the Reus-Tarragona Birth Cohort two hundred and twelve mother-child dyads were followed up during pregnancy and children at 7.5 years. The prevalence of child hypertension was 6.2%. Child CT genotype increases the risk of having prehypertension/+hypertension 6.5 times [OR= 6.5 (1.0, 43.5)] in the office BP model. Maternal MTHFR 677 CT genotype increases the risk of having prehypertension/ hypertension and prehypertension 7.4 times [OR= 7.4 (1.0, 55.0)]. The association between the genotypes and prehypertension/ hypertension is maintained aftereven adjusting for classical other risk factors.