학술논문
Postprandial effects of the phosphodiesterase-5 inhibitor tadalafil in people with well-controlled Type 2 diabetes mellitus: a randomized controlled trial.
Document Type
Author
Sjögren, Lovisa; Olausson, Josefin, 1983; Strindberg, Lena, 1955; Mobini, Reza, 1965; Fogelstrand, Per, 1971; Mattsson Hultén, Lillemor, 1951; Jansson, Per-Anders, 1961
Source
Diabetic medicine : a journal of the British Diabetic Association. 33(9)
Subject
Language
English
ISSN
1464-5491
Abstract
Type 2 diabetes mellitus is a serious global health problem that is hard to treat in the long term, prompting great efforts to find new drug targets. Little attention has been paid, however, to the metabolic significance of the microcirculation in insulin-sensitive tissues, despite the fact that microvascular insulin resistance and endothelial dysfunction are closely associated and have been shown to precede Type 2 diabetes [1]. Endothelial nitric oxide plays a major role in mediating the beneficial effects of insulin on capillary recruitment and muscle glucose uptake [2] and in suppression of inflammatory pathways, including those activated by a high-fat diet [3]. This article is protected by copyright. All rights reserved.