학술논문
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Document Type
Author
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc; Alver, Maris; Bao, Yanchun; Clark, David W; Day, Felix R; Furlotte, Nicholas A; Joshi, Peter K; Kemper, Kathryn E; Kleinman, Aaron; Langenberg, Claudia; Mägi, Reedik; Trampush, Joey W; Verma, Shefali Setia; Wu, Yang; Lam, Max; Zhao, Jing Hua; Zheng, Zhili; Boardman, Jason D; Campbell, Harry; Freese, Jeremy; Harris, Kathleen Mullan; Hayward, Caroline; Herd, Pamela; Kumari, Meena; Lencz, Todd; Luan, Jian'an; Malhotra, Anil K; Metspalu, Andres; Milani, Lili; Ong, Ken K; Perry, John R B; Porteous, David J; Ritchie, Marylyn D; Smart, Melissa C; Smith, Blair H; Tung, Joyce Y; Wareham, Nicholas J; Wilson, James F; Beauchamp, Jonathan P; Conley, Dalton C; Esko, Tõnu; Lehrer, Steven F; Magnusson, Patrik K E; Oskarsson, Sven; Pers, Tune H; Robinson, Matthew R; Thom, Kevin; Watson, Chelsea; Chabris, Christopher F; Meyer, Michelle N; Laibson, David I; Yang, Jian; Johannesson, Magnus; Koellinger, Philipp D; Turley, Patrick; Visscher, Peter M; Benjamin, Daniel J; Cesarini, David; Jacobsson, Bo, 1960
Source
Nature genetics. 50(8):1112-1121
Subject
Language
English
ISSN
1546-1718
Abstract
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1million individuals and identify 1,271independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.