학술논문
Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
Document Type
Author
Andersson, Ulrika; Wibom, Carl; Cederquist, Kristina; Aradottir, Steina; Borg, Åke; Armstrong, Georgina N; Shete, Sanjay; Lau, Ching C; Bainbridge, Matthew N; Claus, Elizabeth B; Barnholtz-Sloan, Jill; Lai, Rose; Il'yasova, Dora; Houlston, Richard S; Schildkraut, Joellen; Bernstein, Jonine L; Olson, Sara H; Jenkins, Robert B; Lachance, Daniel H; Wrensch, Margaret; Davis, Faith G; Merrell, Ryan; Johansen, Christoffer; Sadetzki, Siegal; Bondy, Melissa L; Melin, Beatrice S
Source
Neuro-Oncology BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation. 16(10):1333-1340
Subject
Language
English
ISSN
1523-5866
Abstract
Although familial susceptibility to glioma is known, the genetic basis for this susceptibility remains unidentified in the majority of glioma-specific families. An alternative approach to identifying such genes is to examine cancer pedigrees, which include glioma as one of several cancer phenotypes, to determine whether common chromosomal modifications might account for the familial aggregation of glioma and other cancers.