학술논문
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies
Document Type
Author
Laguzzi, F.; Åkesson, A.; Marklund, Matti; Qian, F.; Gigante, B.; Bartz, T. M.; Bassett, J. K.; Birukov, A.; Campos, H.; Hirakawa, Y.; Imamura, F.; Jäger, S.; Lankinen, M.; Murphy, R. A.; Senn, M.; Tanaka, T.; Tintle, N.; Virtanen, J. K.; Yamagishi, K.; Allison, M.; Brouwer, I. A.; De Faire, U.; Eiriksdottir, G.; Ferrucci, L.; Forouhi, N. G.; Geleijnse, J. M.; Hodge, A. M.; Kimura, H.; Laakso, M.; Risérus, Ulf, 1967; van Westing, A. C.; Bandinelli, S.; Baylin, A.; Giles, G. G.; Gudnason, V.; Iso, H.; Lemaitre, R. N.; Ninomiya, T.; Post, W. S.; Psaty, B. M.; Salonen, J. T.; Schulze, M. B.; Tsai, M. Y.; Uusitupa, M.; Wareham, N. J.; Oh, S.-W.; Wood, A. C.; Harris, W. S.; Siscovick, D.; Mozaffarian, D.; Leander, K.
Source
Circulation. 149(4):305-316
Subject
Language
English
Abstract
BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction.RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions.CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.