학술논문
The cancer genome atlas pan-cancer analysis project
Document Type
Author
Weinstein, John N.; Collisson, Eric A.; Mills, Gordon B.; Shaw, Kenna R Mills; Ozenberger, Brad A.; Ellrott, Kyle; Sander, Chris; Stuart, Joshua M.; Chang, Kyle; Creighton, Chad J.; Davis, Caleb; Donehower, Lawrence; Drummond, Jennifer; Wheeler, David; Ally, Adrian; Balasundaram, Miruna; Birol, Inanc; Butterfield, Yaron S.N.; Chu, Andy; Chuah, Eric; Chun, Hye-Jung E.; Dhalla, Noreen; Guin, Ranabir; Hirst, Martin; Hirst, Carrie; Holt, Robert A.; Jones, Steven J.M.; Lee, Darlene; Li, Haiyan I.; Marra, Marco A.; Mayo, Michael; Moore, Richard A.; Mungall, Andrew J.; Robertson, A Gordon; Schein, Jacqueline E.; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Varhol, Richard J.; Beroukhim, Rameen; Bhatt, Ami S.; Brooks, Angela N.; Cherniack, Andrew D.; Freeman, Samuel S.; Gabriel, Stacey B.; Helman, Elena; Jung, Joonil; Meyerson, Matthew; Ojesina, Akinyemi I.; Pedamallu, Chandra Sekhar; Saksena, Gordon; Schumacher, Steven E.; Tabak, Barbara; Zack, Travis; Lander, Eric S.; Bristow, Christopher A.; Hadjipanayis, Angela; Haseley, Psalm; Kucherlapati, Raju; Lee, Semin; Lee, Eunjung; Luquette, Lovelace J.; Mahadeshwar, Harshad S.; Pantazi, Angeliki; Parfenov, Michael; Park, Peter J.; Protopopov, Alexei; Ren, Xiaojia; Santoso, Netty; Seidman, Jonathan; Seth, Sahil; Song, Xingzhi; Tang, Jiabin; Xi, Ruibin; Xu, Andrew W.; Yang, Lixing; Zeng, Dong; Auman, J Todd; Balu, Saianand; Buda, Elizabeth; Fan, Cheng; Hoadley, Katherine A.; Jones, Corbin D.; Meng, Shaowu; Mieczkowski, Piotr A.; Parker, Joel S; Perou, Charles M.; Roach, Jeffrey; Shi, Yan; Silva, Grace O.; Tan, Donghui; Veluvolu, Umadevi; Waring, Scot; Wilkerson, Matthew D.; Wu, Junyuan; Zhao, Wei; Bodenheimer, Tom; Hayes, D Neil; Hoyle, Alan P.; Jeffreys, Stuart R.; Mose, Lisle E.; Simons, Janae V.; Soloway, Mathew G.; Baylin, Stephen B.; Berman, Benjamin P.; Bootwalla, Moiz S.; Danilova, Ludmila; Herman, James G.; Hinoue, Toshinori; Laird, Peter W.; Rhie, Suhn K.; Shen, Hui; Triche, Timothy; Weisenberger, Daniel J.; Carter, Scott L.; Cibulskis, Kristian; Chin, Lynda; Zhang, Jianhua; Sougnez, Carrie; Wang, Min; Getz, Gad; Dinh, Huyen; Doddapaneni, Harsha Vardhan; Gibbs, Richard; Gunaratne, Preethi; Han, Yi; Kalra, Divya; Kovar, Christie; Lewis, Lora; Morgan, Margaret; Morton, Donna; Muzny, Donna; Reid, Jeffrey; Xi, Liu; Cho, Juok; Dicara, Daniel; Frazer, Scott; Gehlenborg, Nils; Heiman, David I.; Kim, Jaegil; Lawrence, Michael S.; Lin, Pei; Liu, Yingchun; Noble, Michael S.; Stojanov, Petar; Voet, Doug; Zhang, Hailei; Zou, Lihua; Stewart, Chip; Bernard, Brady; Bressler, Ryan; Eakin, Andrea; Iype, Lisa; Knijnenburg, Theo; Kramer, Roger; Kreisberg, Richard; Leinonen, Kalle; Lin, Jake; Liu, Yuexin; Miller, Michael; Reynolds, Sheila M.; Rovira, Hector; Shmulevich, Ilya; Thorsson, Vesteinn; Yang, Da; Zhang, Wei; Amin, Samirkumar; Wu, Chang-Jiun; Wu, Chia-Chin; Akbani, Rehan; Aldape, Kenneth; Baggerly, Keith A.; Broom, Bradley; Casasent, Tod D.; Cleland, James; Dodda, Deepti; Edgerton, Mary; Han, Leng; Herbrich, Shelley M.; Ju, Zhenlin; Kim, Hoon; Lerner, Seth; Li, Jun; Liang, Han; Liu, Wenbin; Lorenzi, Philip L.; Lu, Yiling; Melott, James; Nguyen, Lam; Su, Xiaoping; Verhaak, Roeland; Wang, Wenyi; Wong, Andrew; Yang, Yang; Yao, Jun; Yao, Rong; Yoshihara, Kosuke; Yuan, Yuan; Yung, Alfred K.; Zhang, Nianxiang; Zheng, Siyuan; Ryan, Michael; Kane, David W.; Aksoy, B Arman; Ciriello, Giovanni; Dresdner, Gideon; Gao, Jianjiong; Gross, Benjamin; Jacobsen, Anders; Kahles, Andre; Ladanyi, Marc; Lee, William; Lehmann, Kjong-Van; Miller, Martin L.; Ramirez, Ricardo; Rätsch, Gunnar; Reva, Boris; Schultz, Nikolaus; Senbabaoglu, Yasin; Shen, Ronglai; Sinha, Rileen; Sumer, S Onur; Sun, Yichao; Taylor, Barry S.; Weinhold, Nils; Fei, Suzanne; Spellman, Paul; Benz, Christopher; Carlin, Daniel; Cline, Melisssa; Craft, Brian; Goldman, Mary; Haussler, David; Ma, Singer; Ng, Sam; Paull, Evan; Radenbaugh, Amie; Salama, Sofie; Sokolov, Artem; Swatloski, Teresa; Uzunangelov, Vladislav; Waltman, Peter; Yau, Christina; Zhu, Jing; Hamilton, Stanley R.; Abbott, Scott; Abbott, Rachel; Dees, Nathan D.; Delehaunty, Kim; Ding, Li; Dooling, David J.; Eldred, Jim M.; Fronick, Catrina C.; Fulton, Robert; Fulton, Lucinda L.; Kalicki-Veizer, Joelle; Kanchi, Krishna-Latha; Kandoth, Cyriac; Koboldt, Daniel C.; Larson, David E.; Ley, Timothy J.; Lin, Ling; Lu, Charles; Magrini, Vincent J.; Mardis, Elaine R.; McLellan, Michael D.; McMichael, Joshua F.; Miller, Christopher A.; O'Laughlin, Michelle; Pohl, Craig; Schmidt, Heather; Smith, Scott M.; Walker, Jason; Wallis, John W.; Wendl, Michael C.; Wilson, Richard K.; Wylie, Todd; Zhang, Qunyuan; Burton, Robert; Jensen, Mark A.; Kahn, Ari; Pihl, Todd; Pot, David; Wan, Yunhu; Levine, Douglas A.; Black, Aaron D.; Bowen, Jay; Frick, Jessica; Gastier-Foster, Julie M.; Harper, Hollie A.; Helsel, Carmen; Leraas, Kristen M.; Lichtenberg, Tara M.; McAllister, Cynthia; Ramirez, Nilsa C.; Sharpe, Samantha; Wise, Lisa; Zmuda, Erik; Chanock, Stephen J.; Davidsen, Tanja; Demchok, John A.; Eley, Greg; Felau, Ina; Sheth, Margi; Sofia, Heidi; Staudt, Louis; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Zhang, Jiashan; Omberg, Larsson; Margolin, Adam; Raphael, Benjamin J.; Vandin, Fabio; Wu, Hsin-Ta; Leiserson, Mark D.M.; Benz, Stephen C.; Vaske, Charles J.; Noushmehr, Houtan; Wolf, Denise; Veer, Laura Van'T; Anastassiou, Dimitris; Yang, Tai-Hsien Ou; Lopez-Bigas, Nuria; Gonzalez-Perez, Abel; Tamborero, David; Xia, Zheng; Li, Wei; Cho, Dong-Yeon; Przytycka, Teresa; Hamilton, Mark; McGuire, Sean; Nelander, S.; Johansson, Patrik; Jörnsten, Rebecka, 1971; Kling, Teresia, 1985; Sánchez, José, 1979
Source
Nature Genetics. 45(10):1113-1120
Subject
Language
English
ISSN
1061-4036
Abstract
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.