학술논문
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
Document Type
Author
Ferreira, P. C. L.; Therriault, J.; Tissot, C.; Ferrari-Souza, J. P.; Lessa Benedet, Andréa; Povala, G.; Bellaver, B.; Leffa, D. T.; Brum, W. S.; Lussier, F. Z.; Bezgin, G.; Servaes, S.; Vermeiren, M.; Macedo, A. C.; Cabrera, A.; Stevenson, J.; Triana-Baltzer, G.; Kolb, H.; Rahmouni, N.; Klunk, W. E.; Lopez, O. L.; Villemagne, V. L.; Cohen, A.; Tudorascu, D. L.; Zimmer, E. R.; Karikari, Thomas; Ashton, Nicholas J.; Zetterberg, Henrik, 1973; Blennow, K.; Gauthier, S.; Rosa-Neto, P.; Pascoal, T. A.
Source
Alzheimers & Dementia. 19(10):4463-4474
Subject
Language
English
ISSN
1552-5260
Abstract
INTRODUCTIONPhosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-& beta; (A & beta;) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify A & beta; and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI). METHODSWe assessed 138 CU and 87 CI with available plasma p-tau231, 217(+), and 181, A & beta;42/40, GFAP and A & beta;- and tau-PET. RESULTSIn CU, only plasma p-tau231 and p-tau217(+) significantly improved the performance of the demographics in detecting A & beta;-PET positivity, while no plasma biomarker provided additional information to identify tau-PET positivity. In CI, p-tau217(+) and GFAP significantly contributed to demographics to identify both A & beta;-PET and tau-PET positivity, while p-tau231 only provided additional information to identify tau-PET positivity. DISCUSSIONOur results support plasma p-tau231 and p-tau217(+) as state markers of early A & beta; deposition, but in later disease stages they inform on tau tangle accumulation. HighlightsIt is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex).Plasma p-tau231 and p-tau217(+) contribute to demographic information to identify brain A & beta; pathology in preclinical AD.In CI individuals, plasma p-tau231 contributes to age and sex to inform on the accumulation of tau tangles, while p-tau217(+) and GFAP inform on both A & beta; deposition and tau pathology.