학술논문

THE EFFECT OF A SINGLE GAMMA DOSE ON THE FREQUENCY OF OCCURRENCE OF OVARIAN TUMORS IN MICE
Document Type
Journal Article
Author
Source
Doklady Akad. Nauk S.S.S.R.; Vol: 143; Other Information: Orig. Receipt Date: 31-DEC-62
Subject
BIOLOGY AND MEDICINE CARCINOGENESIS
COBALT 60
CYTOLOGY
GAMMA RADIATION
GONADS
HORMONES
LIFETIME
MICE
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
TUMORS
Language
Russian
Abstract
White mice were given single, whole-body doses of 100, natural death of the irradiated mice, cytological studies were made on various organs of the mice. The tumors formed as a result of radiation were classified as tubular adenomas, granular, luteal, nodular, and complex. The irradiated mice had 203 tumors as compared to 7 tumors in the control group. The frequency of tumor occurrence increased from 33.8% at a dose of 100 r to a maximum of 46.5% at a dose of 200 r, and then fell off gradually. The luteal and granular tumors predominated at a dose of 100 r, while the tubular adenomas were at a maximum at a dose of 200 r. Signs of increased hormonal activity were lacking in mice with tubular adenomas, while the mice with the other types of tumors showed signs of increased hormonal activity. (TTT)