학술논문

Lateral diffusion in an archipelago - effects of impermeable patches on diffusion in a cell membrane
Document Type
Journal Article
Author
Source
Biophys. J.; (United States); 39:2
Subject
59 BASIC BIOLOGICAL SCIENCES CELL MEMBRANES
MOLECULAR BIOLOGY
LIPIDS
CONFIGURATION INTERACTION
PROTEINS
DIFFUSION
PERMEABILITY
CELL CONSTITUENTS
MEMBRANES
ORGANIC COMPOUNDS 550300* -- Cytology
Language
English
Abstract
Lateral diffusion of molecules in lipid bilayer membranes can be hindered by the presence of impermeable domains of gel-phase lipid or of proteins. Effective-medium theory and percolation theory are used to evaluate the effective lateral diffusion constant as a function of the area fraction of fluid-phase lipid and the permeability of the obstructions to the diffusing species. Applications include the estimation of the minimum fraction of fluid lipid needed for bacterial growth, and the enhancement of diffusion-controlled reactions by the channeling effect of solid patches of lipid.