학술논문
Studies on tumor necrosis factor (TNF): II. Metabolic fate and distribution of human recombinant TNF
Document Type
Journal Article
Author
Source
Lymphokine Res.; (United States); 1
Subject
Language
English
Abstract
We have evaluated the fate of cold and /sup 125/I- human recombinant tumor necrosis factor (RTNF) using isolated organs such as rabbit and monkey livers and rabbit kidney and lungs. We have also evaluated the body distribution of the total radioactivity after iv administration of /sup 125/I-RTNF in the rabbits. Monkey and rabbit livers play little catabolic role for RTNF. Lungs do not catabolize TNF at all, while the kidney appears to be the main catabolic organ. Accordingly, the body distribution of /sup 125/I-RTNF shows that most of the radioactivity is concentrated in the kidneys.