부산대학교 도서관

Purpose:[18F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism.Procedures:[18F]-FEPPA whole body PET scans were acquired for six healthy subjects. Time–activity curves were generated from regions of interest of nine organs, from which normalized accumulated activities were calculated and thus internal dose, using OLINDA/EXM 1.1. Genotyping of rs6971, associated with high- and low-affinity [18F]-FEPPA binding (high-affinity binder (HAB) and low-affinity binder (LAB)), was performed.Results:Five subjects exhibited the C/C (HAB) allele, and the other carried the minor allele T/T (LAB). The LAB whole body biodistribution showed highest radioactivity accumulation in bladder, whereas in HABs, the spleen received the highest dose. The effective dose of the single LAB (16.3 μSv/MBq) was 23 % less than the mean of the HABs (21.0 ± 2.9 μSv/MBq). When including all subjects, the effective dose was 20.2 ± 3.0 μSv/MBq.Conclusions:[18F]-FEPPA radiation dose is consistent with other 18F-labeled radioligands and the Ala147Thr genotype agreed with [18F]-FEPPA distribution.