학술논문
Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina
Document Type
Original Paper
Author
Carnero Contentti, Edgar; López, Pablo A.; Pappolla, Agustín; Alonso, Ricardo; Silva, Berenice; Deri, Norma; Balbuena, María E.; Burgos, Marcos; Luetic, Geraldine; Alvez Pinheiro, Amelia; Cabrera, Mariela; Hryb, Javier; Nofal, Pedro; Pestchanker, Claudia; Vrech, Carlos; Tavolini, Darío; Tkachuk, Verónica; Zanga, Gisela; Marrodan, Mariano; Ysrraelit, María Célica; Correale, Jorge; Carrá, Adriana; Federico, Belén; Garcea, Orlando; Fernandez Liguori, Nora; Patrucco, Liliana; Cristiano, Edgardo; Giunta, Diego; Alonso Serena, Marina; Rojas, Juan I.
Source
Neurological Sciences. 45(2):379-389
Subject
Language
English
ISSN
1590-1874
1590-3478
1590-3478
Abstract
We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina (RelevarEM).Methods: Non-interventional, retrospective cohort study that collected information directly from RelevarEM. Adult PwMS who had been treated for at least 6 months with a HET (ocrelizumab, natalizumab, alemtuzumab, cladribine) who had received at least two doses of SARS-CoV-2 vaccines available in Argentina were included. Full course of vaccination was considered after the second dose of the corresponding vaccines. Cumulative incidence of SARS-CoV-2 infection was reported for the whole cohort by Kaplan–Meier survival curves (which is expressed in percentage) as well as incidence density (which is expressed per 10.000 patients/day with 95% CI).Results: Two hundred twenty-eight PwMS were included. Most frequent first and second dose received was AstraZeneca vaccine, followed by Sputnik vaccine. Most frequent HETs used in included patients were cladribine in 79 (34.8%). We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. We described the incidence rate after vaccination for every HET used, it being significantly higher for ocrelizumab compared with other HETs (p = 0.005). Only five patients presented a relapse during the follow-up period with no differences regarding the pre-vaccination period.Conclusions: We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina.