학술논문
Changes of percentages in immune cells phenotypes and cytokines production during two-year IFN-β-1a treatment in multiple sclerosis patients
Document Type
Original Paper
Author
Source
Journal of Neurology. October 2003 250(10):1229-1236
Subject
Language
English
ISSN
0340-5354
1432-1459
1432-1459
Abstract
Abstract.:Objective::The aim of the study was to find out whether INF-β-1ainfluences the immune profile of peripheral blood (PB)leukocytes in MS patients.Method::We have studied 20 patients with relapsing-remitting formof MS treated with INF-β-1a using twocolor cytometry. Wedetermined immune cells phenotypes and production of somecytokines: IL-4, IL-10, IL-12, IFN-γ, before drug administrationand after starting the treatment.Results::In MS patients an increased percentage ofCD14+ CD86+ cells andCD3+ CD25+ cells was noticed after 6, 9 and 12 months of INF-β-1a therapy.Among cytokine-producing cells we noted an increased fraction ofCD3+ IL-4,CD14+ IL-10 andCD14+ IL-12 cells after 12 months,which decreased to the level observed before treatment after24-month therapy.Conclusions::IFN-β-1a treatment was associated with significant changesin immune response. This effect was mostly evident within thefirst year of treatment.