학술논문
Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole
Document Type
Brief Communication
Author
de Souza, Lais Cavalcanti dos Santos Velasco; Reis, Nathália Faria; Alcântara, Lucas Martins; da Silveira Souto, Simone Rocha Leal; de Araújo Penna, Bruno; Santos, Renan Caetano Souza; Robbs, Bruno Kaufmann; Machado, Francisco Paiva; Castro, Helena Carla; Machado, Ricardo Luiz Dantas; Rocha, Leandro; de Souza Baptista, Andréa Regina
Source
Brazilian Journal of Microbiology. 54(1):579-586
Subject
Language
English
ISSN
1517-8382
1678-4405
1678-4405
Abstract
Sporothrix brasiliensis with low susceptibility isolates were described from the Brazilian zoonotic sporotrichosis hyperendemics. The aim of this work was to evaluate distinct fractions of Ocotea pulchella, Ocotea notata, Myrciaria floribunda, and Hypericum brasiliense plant extracts against itraconazole-sensitive and low susceptibility S. brasiliensis isolates. Crude extracts were tested against clinical isolates and the ATCC MYA4823 to determine the minimum inhibitory concentrations (MICs) and fungicidal or fungistatic activities (MFC). A high MICs and MFCs amplitude (1 – > 128 µg/mL) were obtained for seven extracts. The highest antimicrobial activities against sensitive S. brasiliensis were displayed by the ethyl acetate extracts of O. notata (MIC = 2–128 μg/mL) and M. floribunda (MIC = 1–8 μg/mL). A fungicidal effect was observed for all fraction extracts. Ocotea spp. and M. floribunda ethyl acetate extracts provide promising profiles against itraconazole-sensitive or low susceptibility S. brasiliensis. Future studies will determine if these extracts can contribute as alternative therapies to this neglected zoonosis.