학술논문
Electrochemical sensor for hydrogen sulfide detection using electrocatalysis-assisted amplification and chemical reaction-mediated signal enhancement
Document Type
Original Paper
Source
Microchimica Acta: Analytical Sciences and Technologies on the Micro- and Nanoscale. 190(12)
Subject
Language
English
ISSN
0026-3672
1436-5073
1436-5073
Abstract
An ultrasensitive electrochemical biosensing platform has been designed by combining electrocatalysis-assisted H2 S amplification with a chemical reaction-mediated electrochemical signal-boosted system for H2 S detection based on Cu-Mn(OH)2 hexagonal nanorings. The signal amplification is initiated by an electrocatalysis reaction that can grasp specific H2 S substrates and further highly amplify electrochemical signals. Then, the unique chemical reaction is powered by copper ion and generates a large amount of electroactive Cux S products on the electrode surface, thus achieving the multiple amplification of H2 S detection. Finally, the Cu-Mn(OH)2 loaded with plenty of electroactive Cux S can be captured on the electrode for further improving the electrochemical signal thus obtaining ultra-high sensitive determination of H2 S. The established electrochemical biosensing platform displays a wide analytical range of 0.1 μM to 265 μM with a low detection limit of 0.096 μM. The satisfactory selectivity allows the electrochemical sensor to distinguish H2 S from other interfering substances without any complicated pretreatment, even in complex tumor cell samples. Thus, our designed electrocatalysis-assisted amplification strategy offers a powerful analysis toolkit for the early determination of H2 S-related disease in clinical diagnosis.Graphical Abstract: