학술논문
Facile Synthesis of Carboxamide-Substituted 1,3,4-Thiadiazines and 5,6-Dihydro-4H-1,3,4-Thiadiazin-5-Ols
Document Type
Original Paper
Author
Source
Chemistry of Heterocyclic Compounds. 55(7):665-671
Subject
Language
English
ISSN
0009-3122
1573-8353
1573-8353
Abstract
Novel 2-carboxamide-substituted 1,3,4-thiadiazines and 5,6-dihydro-4H-1,3,4-thiadiazin-5-ols were synthesized by the reaction of oxamic acid thiohydrazides with phenacyl bromides. This reaction was performed using an equimolar mixture of thiohydrazide and α-bromoacetophenones in methanol under basic conditions. The ratio of products obtained in the cyclocondensation was found to be strongly dependent on the substitution pattern and reaction conditions.