학술논문
Distribution of drugs following controlled delivery to the brain interstitium
Document Type
Original Paper
Source
Journal of Neuro-Oncology. November 1995 26(2):91-102
Subject
Language
English
ISSN
0167-594X
1573-7373
1573-7373
Abstract
Intracranial controlled release polymers have been used for drug delivery to the brain, bypassing the blood brain barrier (BBB). By understanding the rates and patterns of transport in the local tissues, it is possible to design delivery systems that provide the optimal spatial and temporal pattern of chemotherapy within the intracranial space. This paper reviews the kinetics of drug release from polymeric controlled release implants, and describes the fate of drug molecules following release into the brain interstitium. Potential improvements in drug delivery based on the understanding of the mechanisms of drug release, transport and elimination are discussed.