학술논문

Revisiting the therapeutic potential of gingerols against different pharmacological activities
Document Type
Review Paper
Source
Naunyn-Schmiedeberg's Archives of Pharmacology. 396(4):633-647
Subject
Ginger
Gingerol
Zingiber officinale
Volatile oil
Resins
Cancer
Inflammation
Language
English
ISSN
0028-1298
1432-1912
Abstract
The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases.Graphical Abstract: