학술논문
A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection
Document Type
Review Paper
Author
Narayanan, S. Anand; Jamison, Jr, David A.; Guarnieri, Joseph W.; Zaksas, Victoria; Topper, Michael; Koutnik, Andrew P.; Park, Jiwoon; Clark, Kevin B.; Enguita, Francisco J.; Leitão, Ana Lúcia; Das, Saswati; Moraes-Vieira, Pedro M.; Galeano, Diego; Mason, Christopher E.; Trovão, Nídia S.; Schwartz, Robert E.; Schisler, Jonathan C.; Coelho-dos-Reis, Jordana G. A.; Wurtele, Eve Syrkin; Beheshti, Afshin
Source
European Journal of Human Genetics. 32(1):10-20
Subject
Language
English
ISSN
1018-4813
1476-5438
1476-5438
Abstract
COVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and mortality worldwide. The betacoronavirus continues to evolve with global health implications as we race to learn more to curb its transmission, evolution, and sequelae. The focus of this review, the second of a three-part series, is on the biological effects of the SARS-CoV-2 virus on post-acute disease in the context of tissue and organ adaptations and damage. We highlight the current knowledge and describe how virological, animal, and clinical studies have shed light on the mechanisms driving the varied clinical diagnoses and observations of COVID-19 patients. Moreover, we describe how investigations into SARS-CoV-2 effects have informed the understanding of viral pathogenesis and provide innovative pathways for future research on the mechanisms of viral diseases.