학술논문
The oldest unvaccinated Covid-19 survivors in South America
Document Type
Original Paper
Author
de Castro, Mateus V.; Silva, Monize V. R.; Naslavsky, Michel S.; Scliar, Marilia O.; Nunes, Kelly; Passos-Bueno, Maria Rita; Castelli, Erick C.; Magawa, Jhosiene Y.; Adami, Flávia L.; Moretti, Ana I. S.; de Oliveira, Vivian L.; Boscardin, Silvia B.; Cunha-Neto, Edecio; Kalil, Jorge; Jouanguy, Emmanuelle; Bastard, Paul; Casanova, Jean-Laurent; Quiñones-Vega, Mauricio; Sosa-Acosta, Patricia; Guedes, Jéssica de S.; de Almeida, Natália P.; Nogueira, Fábio C. S.; Domont, Gilberto B.; Santos, Keity S.; Zatz, Mayana
Source
Immunity & Ageing. 19(1)
Subject
Language
English
ISSN
1742-4933
Abstract
Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated.Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN.Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.