학술논문
Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria
Document Type
Original Paper
Author
Olawoye, Idowu B.; Oluniyi, Paul E.; Oguzie, Judith U.; Uwanibe, Jessica N.; Kayode, Tolulope A.; Olumade, Testimony J.; Ajogbasile, Fehintola V.; Parker, Edyth; Eromon, Philomena E.; Abechi, Priscilla; Sobajo, Tope A.; Ugwu, Chinedu A.; George, Uwem E.; Ayoade, Femi; Akano, Kazeem; Oyejide, Nicholas E.; Nosamiefan, Iguosadolo; Fred-Akintunwa, Iyanuoluwa; Adedotun-Sulaiman, Kemi; Brimmo, Farida B.; Adegboyega, Babatunde B.; Philip, Courage; Adeleke, Richard A.; Chukwu, Grace C.; Ahmed, Muhammad I.; Ope-Ewe, Oludayo O.; Otitoola, Shobi G.; Ogunsanya, Olusola A.; Saibu, Mudasiru F.; Sijuwola, Ayotunde E.; Ezekiel, Grace O.; John, Oluwagboadurami G.; Akin-John, Julie O.; Akinlo, Oluwasemilogo O.; Fayemi, Olanrewaju O.; Ipaye, Testimony O.; Nwodo, Deborah C.; Omoniyi, Abolade E.; Omwanghe, Iyobosa B.; Terkuma, Christabel A.; Okolie, Johnson; Ayo-Ale, Olubukola; Ikponmwosa, Odia; Benevolence, Ebo; Naregose, Grace O.; Patience, Akhilomen E.; Blessing, Osiemi; Micheal, Airende; Jacqueline, Agbukor; Aiyepada, John O.; Ebhodaghe, Paulson; Racheal, Omiunu; Rita, Esumeh; Rosemary, Giwa E.; Solomon, Ehikhametalor; Anieno, Ekanem; Edna, Yerumoh; Chris, Aire O.; Donatus, Adomeh I.; Ogbaini-Emovon, Ephraim; Tatfeng, Mirabeau Y.; Omunakwe, Hannah E.; Bob-Manuel, Mienye; Ahmed, Rahaman A.; Onwuamah, Chika K.; Shaibu, Joseph O.; Okwuraiwe, Azuka; Ataga, Anthony E.; Bock-Oruma, Andrew; Daramola, Funmi; Yusuf, Ibrahim F.; Fajola, Akinwumi; Ntia, Nsikak-Abasi; Ekpo, Julie J.; Moses, Anietie E.; Moore-Igwe, Beatrice W.; Fakayode, Oluwatosin E.; Akinola, Monilade; Kida, Ibrahim M.; Oderinde, Bamidele S.; Wudiri, Zara W.; Adeyemi, Oluwapelumi O.; Akanbi, Olusola A.; Ahumibe, Anthony; Akinpelu, Afolabi; Ayansola, Oyeronke; Babatunde, Olajumoke; Omoare, Adesuyi A.; Chukwu, Chimaobi; Mba, Nwando G.; Omoruyi, Ewean C.; Olisa, Olasunkanmi; Akande, Olatunji K.; Nwafor, Ifeanyi E.; Ekeh, Matthew A.; Ndoma, Erim; Ewah, Richard L.; Duruihuoma, Rosemary O.; Abu, Augustine; Odeh, Elizabeth; Onyia, Venatius; Ojide, Chiedozie K.; Okoro, Sylvanus; Igwe, Daniel; Ogah, Emeka O.; Khan, Kamran; Ajayi, Nnennaya A.; Ugwu, Collins N.; Ukwaja, Kingsley N.; Ugwu, Ngozi I.; Abejegah, Chukwuyem; Adedosu, Nelson; Ayodeji, Olufemi; Liasu, Ahmed A.; Isamotu, Rafiu O.; Gadzama, Galadima; Petros, Brittany A.; Siddle, Katherine J.; Schaffner, Stephen F.; Akpede, George; Erameh, Cyril Oshomah; Baba, Marycelin M.; Oladiji, Femi; Audu, Rosemary; Ndodo, Nnaemeka; Fowotade, Adeola; Okogbenin, Sylvanus; Okokhere, Peter O.; Park, Danny J.; Mcannis, Bronwyn L.; Adetifa, Ifedayo M.; Ihekweazu, Chikwe; Salako, Babatunde L.; Tomori, Oyewale; Happi, Anise N.; Folarin, Onikepe A.; Andersen, Kristian G.; Sabeti, Pardis C.; Happi, Christian T.
Source
Nature Communications. 14(1)
Subject
Language
English
ISSN
2041-1723
Abstract
Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates.
Data on geographically restricted SARS-CoV-2 variants is lacking in some regions. In this nationwide effort including 18 public health labs, the authors used genomic epidemiology and travel data to understand the origin and spread of 2 variants of interest that predominated during the second wave of the pandemic in Nigeria.
Data on geographically restricted SARS-CoV-2 variants is lacking in some regions. In this nationwide effort including 18 public health labs, the authors used genomic epidemiology and travel data to understand the origin and spread of 2 variants of interest that predominated during the second wave of the pandemic in Nigeria.