부산대학교 도서관

Reliable visualization of the hippocampus on echo-planar imaging (EPI) is essential in analyzing memory function using functional magnetic resonance imaging. However, the hippocampal area is notoriously prone to susceptibility artifacts caused by structures at the skull base, and avoiding such artifacts by appropriately selecting the subjects for a study is of practical importance. To elucidate factors affecting the extent of the artifacts we obtained EPI in a total of 62 hippocampi from 31 healthy volunteers and evaluated various anatomical measurements possibly associated with the quality of the images. The hippocampal head was sufficiently well demonstrated on 40 of 62 images (65%), and there were two parameters that significantly differed between the good (n=40) and poor (n=22) imaging studies: The vertical diameter (DV) of the opening of the internal acoustic meatus (IAM) and the pneumatization rate of the sphenoid sinus (RP-SS). From logistic regression analysis with the stepwise method, in addition to these two factors, the distance between the hippocampal body and IAM (Dhippo-IAM) and the distance between the hippocampal head and the middle cranial fossa at the skull base (Dhippo-base) were extracted. DV-IAM, RP-SS, and Dhippo-base were negatively correlated with the good imaging of the hippocampal head. On the other hand, Dhippo-IAM was positively correlated. These easily measurable parameters will be helpful in selecting subjects and in increasing the efficiency of hippocampal visualization in studies on human memory function.