부산대학교 도서관

Spine fusion is considered to be the gold standard for the treatment of most degenerative and traumatic spinal conditions. Bone graft is still the best choice to achieve fusion and currently autologous and allograft bone are the main sources for bone grafting procedures. Autologous bone has by far the most osteogenic potential, but it is limited and it can lead to a donor site pain condition. Allograft bone is an important source when structural or large volumes of grafts are required. Concerns related to the use of both autografts and allografts has led to the search for alternatives, but synthetic bone graft substitutes as yet offer only a partial solution to the management of localized bone loss. They possess some of the desired mechanical qualities of bone as well as osteointegrative/conductive properties, but are largely reliant on viable periosteum/bone for their success. The advent of composite synthetic bone graft substitutes and biologically active factors is moving closer to the goal of obtaining a synthetic bone graft substitute that mimics the native bone in both mechanical and osteogenic properties.