부산대학교 도서관

Data are presented on ligands based on bombesin derivatives, which are peptides that specifically bind to gastrin-releasing factor receptors, that are promising for use in nuclear medicine. An analysis of developments related to the creation of radiopharmaceuticals (RPs) based on gastrin-releasing peptide-receptor agonists for radionuclide diagnostics and systemic radiation therapy is carried out. The stages of pharmaceutical development of the first Russian RPs 68Ga-NOTA-AMBA and 177Lu-DOTA-AMBA are described, including the synthesis technology using automated modules, as well as drug specifications.