학술논문
Preparation of nanomagnetic alginate modified by histidine as an antibacterial agent and a reusable green catalyst for the three-component synthesis of 2-amino-4H-chromenes and tetrahydropyrimidines
Document Type
Original Paper
Source
Research on Chemical Intermediates. 50(2):905-924
Subject
Language
English
ISSN
0922-6168
1568-5675
1568-5675
Abstract
A novel acid–base nanocatalyst (MNPs@Alg-Pr-His) was synthesized using available materials (nanomagnetic alginate core and histidine) via a facile strategy. After characterization, its efficiency was investigated in the synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine derivatives. This nanobiocatalyst showed remarkable catalytic efficiency in both reactions (the reaction yields for the first reaction: 89–96% and for the second reaction: 68–85%). This catalyst was reusable and recyclable and still showed good activity after five runs. The antibacterial effect of the histidine, alginate, and MNPs@Alg-Pr-His was evaluated against a Gram-positive bacterium (S.aureus) and a Gram-negative bacterium (E. coli) by the disk diffusion method. It is noticeable that MNPs@Alg-Pr-His, unlike histidine and alginate, showed more antibacterial activity against Gram-negative bacterium (28.0 ± 1.4) than Gram-positive bacterium (19.0 ± 1.4).Graphical Abstract: