학술논문
Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation
Document Type
Original Paper
Author
Source
The Journal of Antibiotics: Official journal of the Society for Actinomycetes, Japan. 70(1):84-89
Subject
Language
English
ISSN
0021-8820
1881-1469
1881-1469
Abstract
In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp. SANK 71903. Four active compounds, ogipeptins A, B, C and D, were isolated from the cultured broth. The structures of these compounds were elucidated by physicochemical data and spectral analyses, and they were determined to be new cyclic lipopeptides.