학술논문
Estimation of Na-blocking efficiency of rihlocaine and its combinations with low-molecular-weight polymers on isolated rat cardiomyocytes
Document Type
Original Paper
Source
Bulletin of Experimental Biology and Medicine. December 1997 124(6):1197-1199
Subject
Language
English
ISSN
0007-4888
1573-8221
1573-8221
Abstract
The effect of glucose-base polymers (dextrans with relative molecular weight 10, 40, and 70 kD) and vinylpyrrolidone (polyvinylpyrrolidone: 10, 24, and 40 kD) on changes in the sarcoplasmic Na+ concentration in stimulated cardiomyocytes (1.0 Hz, 10 msec, 60 mV) were examined. In the concentration range of 1–100 μM, the polymer preparations produced cardioprotective effect on cells incubated under hypoxic conditions; the effect depended on the nature and molecular weight of the polymer. Rihlocaine (25 μM) inhibits by 42% elevation of intracellular Na+ induced by plasma membrane depolarization. Dextran 40 is shown to significantly increase Na-blocking effect of rihlocaine.