부산대학교 도서관

The present study contains a comprehensive study of steroid and umbelliferone-based modified poly(ε-caprolactone)s as a potential carrier for the drug delivery systems. The modified PCLs were successfully synthesized via a combined ring-opening polymerization and “click” chemistry technique. Herein, the α-end of the PCL polymer chain was modified with different bioactive steroidal compounds (cholesterol, pregnenolone, dehydroepiandrosterone, dihydrotestosterone, estradiol), while a natural plant-derived compound (umbelliferone) was conjugated to the ω-end. The chemical structure and molecular characteristics of synthesized materials were confirmed by 1H‐NMR, FTIR, GPC, DSC, TGA, POM, Uv–vis, and fluorescence spectroscopy techniques. The in vitro antimicrobial evaluation of the modified polymeric materials against Gram ( +) (S. aureus, E. faecalis, S. epidermidis) and Gram (-) (E. coli) bacteria as well as fungi (C. albicans) was performed. In addition, in vitro biocompatibility and cytotoxicity were evaluated via MTT assay using fibroblast (L929) and human breast cancer (MCF-7) cell lines. Results suggested that the PCLs containing steroid and umbelliferone possess a promising future in drug delivery applications.