학술논문
Association of TLR8 Variants in Sex-Based Clinical Differences in Patients with COVID-19
Document Type
Original Paper
Author
del Carmen Camacho-Rea, María; Martínez-Gómez, Laura Edith; Martinez-Armenta, Carlos; Martínez-Nava, Gabriela Angélica; Ortega-Peña, Silvestre; Olea-Torres, Jessel; Herrera-López, Brígida; Suarez-Ahedo, Carlos; Vázquez-Cárdenas, Paola; Vidal-Vázquez, Rosa P.; Ramírez-Hinojosa, Juan Pablo; Vargas-Alarcón, Gilberto; Posadas-Sánchez, Rosalinda; Fragoso, José Manuel; De Jesús Martínez-Ruiz, Felipe; Zayago-Angeles, Dulce María; Mata-Miranda, Mónica Maribel; Vazquez-Zapien, Gustavo Jesús; Martínez-Cuazitl, Adriana; Garcia-Galicia, Armando; Granados, Julio; Ramos, Luis; Rodríguez-Pérez, José Manuel; Pineda, Carlos; López-Reyes, Alberto
Source
Biochemical Genetics. :1-22
Subject
Language
English
ISSN
0006-2928
1573-4927
1573-4927
Abstract
The host immune response might confer differential vulnerability to SARS‐CoV‐2 infection. The Toll-like receptor 8 (TLR8), could participated for severe COVID-19 outcomes. To investigated the relationship of TLR8 rs3764879-C/G, rs3764880-A/G, and rs3761624-A/G with COVID‐19 outcomes and with biochemical parameters. A cross-sectional study of 830 laboratory‐confirmed COVID‐19 patients was performed, and classified into mild, severe, critical, and deceased outcomes. The TLR8 rs3764879-C/G, rs3764880-A/G, and rs3761624-A/G polymorphisms were genotyped. A logistic regression analysis was performed to determinate the association with COVID‐19. A stratified analysis was by alleles was done with clinical and metabolic markets. In all outcomes, men presented the highest ferritin levels compared to women (P < 0.001). LDH levels were significantly different between sex in mild (P = 0.003), severe (P < 0.001) and deceased (P = 0.01) COVID-19 outcomes. The GGG haplotype showed an Odds Ratio of 1.55 (Interval Confidence 95% 1.05–2.32; P = 0.03) in men. Among patients with severe outcome, we observed that the carriers of the GGG haplotype had lower Ferritin, C-reactive protein and LDH levels than the CAA carriers (P < 0.01). After further stratified by sex, these associations were also seen in the male patients, except for D-dimer. Interestingly, among men patients, we could observe associations between TLR8 haplotypes and Ferritin (P < 0.001), D-dimer (P = 0.04), C-reactive protein, and Lactate dehydrogenase in mild (P = 0.04) group. Our results suggest that even though TLR8 haplotypes show a significant association with COVID-19 outcomes, they are associated with clinical markers in COVID-19 severity.