학술논문
Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut
Document Type
Original Paper
Author
Vegas Villalmanzo, Blanca; Cantera Estefanía, Rodrigo; Muñoz Madrid, Sara; Cerrato Salas, Mariana; Arnaiz Martín, Irene; Molina Pérez, Marta; Sagrista López, Beatriz; Ruiz Ramírez, Yolanda; Cucharero Martín, Javier; Estival Monteliú, Pablo; Ropero Gradilla, Paloma; Ferrer Benito, Sara; Martín Hernández, María Paz; González Fernández, Fernando Ataulfo; Gómez Álvarez, Miguel; Villegas Martínez, Ana; Benavente Cuesta, Celina; Martínez Nieto, Jorge
Source
Annals of Hematology. 103(3):725-727
Subject
Language
English
ISSN
0939-5555
1432-0584
1432-0584
Abstract
It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms (p<0.001) and ≥ 3 points in the TMA mortality score (p<0.001). In conclusion, the onset of aTTP is associated with worse analytical parameters and severe neurological involvement.