학술논문
Chemotherapy of tuberculosis: Part V. Synthesis of some N4 -acyl-N1 -aryl sulphanilhydroxamides
Document Type
Original Paper
Author
Source
Proceedings of the Indian Academy of Sciences - Section A. March 1950 31(3):183-186
Subject
Language
English
ISSN
0370-0089
Abstract
Summary:A series of sulphanilamides derived from N-carbo and heterocyclic hydroxamides have been synthesised, since a number of N4 -acyl sulphanilhydroxamides have been favourably reported on in preliminary experimental bacterial infections. Among the latter wassulphabenamide or N4 -caproyl sulphanylhydroxamide, which was said to be effective clinically in streptococcal infections and tuberculosis. This is a new class of sulphanilamides involving the preliminary synthesis of some hitherto unknown substituted aryl- and heterocyclic hydroxamides. The compounds of this series so far prepared are the N4 -n-butyryl-, the N4 -n-valeryl-, and the N4 -n-caproylsulphanilyl derivatives of β-3-chlorophenyl-, β-4-chlorophenyl-, β-2∶5-dichlorophenyl-, and β-3∶4-dichlorophenyl-hydroxylamines.