부산대학교 도서관

Six sensitizers [haematoporphyrin derivative (HPD), Photofrin II, themeta-, ortho- andpara- isomers of the tetra(hydroxyphenyl)porphyrins (m-, o-, andp-THPP) and the potassium salt ofp-THPP (K-p-THPP)] were compared in their ability to sensitize mouse skeletal muscle and tumours. Muscle damage was measured as percentage weight increase due to oedema 4h after illumination and as percentage cross-sectional area necrosis at 48h. These results were compared with those that had previously been obtained for depth of necrosis in subcutaneous tumours. All the photosensitizers damaged both tumours and skeletal muscle. Acost (muscle damage) vsbenefit (subcutaneous tumour necrosis) analysis of the results showed thatm-THPP was the most tumour selective sensitizer of those studied. In the long-term, muscle healed by regeneration and some fibrosis with full return of function.