학술논문
Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks
Document Type
Original Paper
Author
Keita, Alpha Kabinet; Koundouno, Fara R.; Faye, Martin; Düx, Ariane; Hinzmann, Julia; Diallo, Haby; Ayouba, Ahidjo; Le Marcis, Frederic; Soropogui, Barré; Ifono, Kékoura; Diagne, Moussa M.; Sow, Mamadou S.; Bore, Joseph A.; Calvignac-Spencer, Sebastien; Vidal, Nicole; Camara, Jacob; Keita, Mamadou B.; Renevey, Annick; Diallo, Amadou; Soumah, Abdoul K.; Millimono, Saa L.; Mari-Saez, Almudena; Diop, Mamadou; Doré, Ahmadou; Soumah, Fodé Y.; Kourouma, Kaka; Vielle, Nathalie J.; Loucoubar, Cheikh; Camara, Ibrahima; Kourouma, Karifa; Annibaldis, Giuditta; Bah, Assaïtou; Thielebein, Anke; Pahlmann, Meike; Pullan, Steven T.; Carroll, Miles W.; Quick, Joshua; Formenty, Pierre; Legand, Anais; Pietro, Karla; Wiley, Michael R.; Tordo, Noel; Peyrefitte, Christophe; McCrone, John T.; Rambaut, Andrew; Sidibé, Youssouf; Barry, Mamadou D.; Kourouma, Madeleine; Saouromou, Cé D.; Condé, Mamadou; Baldé, Moussa; Povogui, Moriba; Keita, Sakoba; Diakite, Mandiou; Bah, Mamadou S.; Sidibe, Amadou; Diakite, Dembo; Sako, Fodé B.; Traore, Fodé A.; Ki-Zerbo, Georges A.; Lemey, Philippe; Günther, Stephan; Kafetzopoulou, Liana E.; Sall, Amadou A.; Delaporte, Eric; Duraffour, Sophie; Faye, Ousmane; Leendertz, Fabian H.; Peeters, Martine; Toure, Abdoulaye; Magassouba, N’. Faly
Source
Nature: International weekly journal of science. 597(7877):539-543
Subject
Language
English
ISSN
0028-0836
1476-4687
1476-4687
Abstract
Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak—between 14 February and 19 June 2021—near the epicentre of the previous epidemic1,2 . Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.
The viral lineage responsible for the February 2021 outbreak of Ebola virus disease in Guinea is nested within a clade that predominantly consists of genomes sampled during the 2013–2016 epidemic, suggesting that the virus might have re-emerged after a long period of latency within a previously infected individual.
The viral lineage responsible for the February 2021 outbreak of Ebola virus disease in Guinea is nested within a clade that predominantly consists of genomes sampled during the 2013–2016 epidemic, suggesting that the virus might have re-emerged after a long period of latency within a previously infected individual.