학술논문
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
Document Type
Original Paper
Author
Norin, Ulrika; Rintisch, Carola; Meng, Liesu; Forster, Florian; Ekman, Diana; Tuncel, Jonatan; Klocke, Katrin; Bäcklund, Johan; Yang, Min; Bonner, Michael Y.; Lahore, Gonzalo Fernandez; James, Jaime; Shchetynsky, Klementy; Bergquist, Maria; Gjertsson, Inger; Hubner, Norbert; Bäckdahl, Liselotte; Holmdahl, Rikard
Source
Nature Communications. 12(1)
Subject
Language
English
ISSN
2041-1723
Abstract
The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that a mutation in the SH3gl1 gene encoding the endocytic protein Endophilin A2 is associated with the development of arthritis in rodents. Defective expression of SH3gl1 affects T cell effector functions and alters the activation threshold of autoreactive T cells, thereby leading to complete protection from chronic autoimmune inflammatory disease in both mice and rats. We further show that SH3GL1 regulates human T cell signaling and T cell receptor internalization, and its expression is upregulated in rheumatoid arthritis patients. Collectively our data identify SH3GL1 as a key regulator of T cell activation, and as a potential target for treatment of autoimmune diseases.
The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hinting a potential target for RA therapy.
The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hinting a potential target for RA therapy.