학술논문
Antiandrogene Strategien im Prostatakarzinom: Rekonstitution des β-Östrogenrezeptors
Document Type
Original Paper
Source
Der Urologe: Organ der Deutschen Gesellschaft für UrologieOrgan des Berufsverbandes der Deutschen Urologen. September 2010 49(9):1124-1130
Subject
Language
German
ISSN
0340-2592
1433-0563
1433-0563
Abstract
In advanced prostate cancer, albeit castration resistant, an active androgen receptor is still pivotal for growth and cell survival. Recent therapies involving more effective antiandrogens such as MDV3100 proved to be successful. Furthermore, blocking de novo intracrine androgen synthesis, e.g. with abiraterone acetate, provides additional benefit. Besides these antiandrogen measures, compounds which enable the reconstitution of the oestrogen receptor beta as a tumour suppressor restrain aberrant androgen receptor signalling.