학술논문
Serotonergic mechanisms are involved in the hemostatic action of erythropoietin in uremic patients
Document Type
Original Paper
Author
Source
International Journal of Clinical and Laboratory Research. December 1993 23(1-4):42-44
Subject
Language
English
ISSN
0940-5437
1434-4467
1434-4467
Abstract
Summary:Recombinant human erythropoietin was administered to 12 patients with end-stage renal failure on long-term hemodialysis. They responded to the therapy with a shortening of the prolonged bleeding time, starting from the 1st week of therapy, before a significant increase in hemoglobin concentration was achieved. We also observed an increase in the activity of tissue plasminogen activator and a decrease in the activity of its inhibitor. There were no changes in platelet count but a significant increase in blood and platelet serotonin concentration was found. The shortening of the prolonged bleeding time before the correction of the anemia correlated with the rise in blood and platelet serotomin concentration during erythropoietin therapy. We suggest the possible involvement of an serotonergic mechanism in the hemostatic action of recombinant human erythropoietin.