부산대학교 도서관

Clinical remission of type 1 diabetes reflects the transient recovery of β-cell function and improvement in insulin sensitivity, occurring after introduction of insulin therapy. The aim of the study was to identify factors associated with early beginning of partial remission phase in patients with newly diagnosed type 1 diabetes. One hundred and sixteen patients (41 women and 75 men), aged 18–34 (mean age 23.8 ± 8.7 years), were included into the study. Mean hospitalization time was 7 ± 2 days. Early remission was defined as reaching total daily insulin dose <0.3 U/kg with correct glycaemia in 24-h (7-point) glycaemic profile before discharge from the hospital, with random serum C-peptide above 0.5 μg/l. In group entering early remission (74 patients), significantly lower HbA1c values (9.6 ± 2.6 vs. 11.5 ± 4.5 %, p < 0.001), higher body mass index (BMI) (21.9 ± 2.9 vs. 20.8 ± 4.2 kg/m2, p < 0.05), less frequent ketonuria (45 vs. 79 %, p < 0.01) and diabetic ketoacidosis (11 vs. 26 %, p = 0.06) were recorded at diagnosis. The results indicate that degree and duration of metabolic disturbances are associated with early beginning of partial remission in young adults with newly diagnosed type 1 diabetes. Early onset of remission is common in this age group.